Using Chrome I tried clicking and running Report Builder in http://rs2k801.discountasp.net/Reports/Pages/Folder.aspx and it would download a file to me, and then give me a security error: Deployment and application do not have matching security zones. Run it in IE - it works there.
The problem is related to all clickonce applications on Chrome or firefox. There are some extension you can download that enables you to use Clickonce app on Chrome or Firefox Chrome https://chrome.google.com/webstore/...e-chro/eeifaoomkminpbeebjdmdojbhmagnncl?hl=en https://code.google.com/p/clickonceforchrome/ Firefox https://addons.mozilla.org/en-us/firefox/addon/microsoft-net-framework-assist/ Important: I have not tested any of these extension personally; use at your own risk